abstract：:Timely administration of thrombolytic therapy decreases myocardial infarct size, lessens the incidence of congestive heart failure and improves survival. However, available data suggest that only 10% of patients with acute infarction in the United States receive thrombolytic drugs. Given the benefits of thrombolytic t...

journal_title：Journal of the American College of Cardiology

authors： Grines CL,DeMaria AN

更新日期：1990-07-01 00:00:00

abstract：:Electrophysiologic and histologic studies were performed on Langendorff-perfused human hearts from patients who underwent heart transplantation because of extensive infarction. In nine hearts, 15 sustained ventricular tachycardias could be induced by programmed stimulation. In all hearts, mapping of epicardial and end...

journal_title：Journal of the American College of Cardiology

authors： de Bakker JM,Coronel R,Tasseron S,Wilde AA,Opthof T,Janse MJ,van Capelle FJ,Becker AE,Jambroes G

更新日期：1990-06-01 00:00:00

abstract：:To investigate prospectively the occurrence and significance of postinfarction transient left ventricular dysfunction, 33 ambulatory patients who underwent thrombolytic therapy after myocardial infarction were monitored continuously for 187 +/- 56 min during normal activity with a radionuclide left ventricular functio...

journal_title：Journal of the American College of Cardiology

authors： Kayden DS,Wackers FJ,Zaret BL

更新日期：1990-06-01 00:00:00

abstract：:Signal-averaged electrocardiograms (ECGs) and programmed ventricular stimulation were serially performed in 12 dogs (3 weeks of age) after experimental anteroapical myocardial infarction. At electrophysiologic study, sustained ventricular tachyarrhythmia was induced in seven dogs on at least one occasion. Of a total o...

journal_title：Journal of the American College of Cardiology

authors： Kuchar DL,Rosenbaum DS,Ruskin J,Garan H

更新日期：1990-05-01 00:00:00

abstract：:The prevalence of an abnormal signal-averaged electrocardiogram (ECG) and ventricular arrhythmias on 24 h ambulatory electrocardiography was evaluated in 118 patients 13 +/- 2 days after acute myocardial infarction. Group 1 (46 patients) underwent intravenous thrombolysis within 6 h of the onset of symptoms, whereas G...

journal_title：Journal of the American College of Cardiology

authors： Turitto G,Risa AL,Zanchi E,Prati PL

更新日期：1990-05-01 00:00:00

abstract：:The prognostic significance of the type of first acute myocardial infarction (Q wave versus non-Q wave) and Q wave location (anterior versus inferoposterior) was determined from a multicenter data base involving 777 placebo-treated patients who were participants in the Multicenter Diltiazem Post-Infarction Trial. Ther...

journal_title：Journal of the American College of Cardiology

authors： Benhorin J,Moss AJ,Oakes D,Marcus F,Greenberg H,Dwyer EM Jr,Algeo S,Hahn E

更新日期：1990-05-01 00:00:00

abstract：:To delineate the role of plasmin inhibitors, especially the two molecular forms of alpha 2-antiplasmin (that is, the plasminogen-binding and the nonplasminogen-binding forms), in the control of systemic effects during thrombolytic therapy, the consumption of plasmin inhibitors and the degree of fibrinogen breakdown we...

journal_title：Journal of the American College of Cardiology

authors： Leebeek FW,Kluft C,Knot EA,Los P,Cohen AF,Six AJ

更新日期：1990-05-01 00:00:00

abstract：:Twenty-nine consecutive patients with symptomatic hypertrophic cardiomyopathy and a mean age of 44.8 +/- 12.2 years (range 21 to 63) underwent complex invasive and noninvasive testing to identify a risk profile for syncope. Clinical, morphologic, electrophysiologic and hemodynamic variables at rest and at a symptom-li...

journal_title：Journal of the American College of Cardiology

authors： Nienaber CA,Hiller S,Spielmann RP,Geiger M,Kuck KH

更新日期：1990-04-01 00:00:00

abstract：:The objectives of this study were to evaluate the effects of alterations in loading induced by lower body negative pressure on aortic blood flow velocity and acceleration. Twenty-seven normal men were studied during various levels of lower body negative pressure (0 to -60 mm Hg) during which echocardiographic, Doppler...

journal_title：Journal of the American College of Cardiology

authors： Berk MR,Evans J,Knapp C,Harrison MR,Kotchen T,DeMaria AN

更新日期：1990-04-01 00:00:00

abstract：:Measurement of systolic wall thickening by sonomicrometry provides an accurate index of regional left ventricular function, but the trauma of crystal insertion limits its widespread clinical use. The first clinical application of a 10 MHz ultrasonic Doppler probe that can be either sutured or applied by suction to the...

journal_title：Journal of the American College of Cardiology

authors： Bolli R,Hartley CJ,Chelly JE,Patel BS,Rabinovitz RS,Jeroudi MO,Roberts R,Noon G

更新日期：1990-04-01 00:00:00

abstract：:Although transient increases in heart rate typically occur, bradycardia has infrequently been noted in association with partial seizures. Five patients with temporal lobe epilepsy are described in whom sinus bradyarrhythmias and syncope were prominent manifestations of seizure activity. Partial improvement occurred in...

journal_title：Journal of the American College of Cardiology

authors： Constantin L,Martins JB,Fincham RW,Dagli RD

更新日期：1990-03-15 00:00:00

abstract：:To investigate the use of high energy ultrasound as an alternative energy for angioplasty, an experimental ultrasonic angioplasty device was developed. The device was studied in two bioassay systems: an in vitro system for the disruption of atherosclerotic plaques and thrombi and an in vivo system for the recanalizati...

journal_title：Journal of the American College of Cardiology

authors： Rosenschein U,Bernstein JJ,DiSegni E,Kaplinsky E,Bernheim J,Rozenzsajn LA

更新日期：1990-03-01 00:00:00

abstract：:Percutaneous transluminal coronary angioplasty was performed as primary therapy in 215 consecutive patients (aged 56 +/- 11 years, 75% male) with acute myocardial infarction and single vessel coronary artery disease. Wide patency of the infarct-related artery was restored in 212 patients (99%). Complications consisted...

journal_title：Journal of the American College of Cardiology

authors： Stone GW,Rutherford BD,McConahay DR,Johnson WL Jr,Giorgi LV,Ligon RW,Hartzler GO

更新日期：1990-03-01 00:00:00

abstract：:Infection of the mitral-aortic intervalvular fibrosa occurs most commonly in association with infective endocarditis of the aortic valve. Infection of the aortic valve results in a regurgitant jet that presumably strikes this subaortic interannular zone of fibrous tissue and produces a secondary site of infection. Inf...

journal_title：Journal of the American College of Cardiology

authors： Bansal RC,Graham BM,Jutzy KR,Shakudo M,Shah PM

更新日期：1990-02-01 00:00:00

abstract：:To determine the feasibility and cost-saving potential of substituting outpatient for inpatient cardiac catheterization, 986 consecutive procedures were studied at a large referral hospital. Patients were classified prospectively as to their eligibility for outpatient cardiac catheterization according to published gui...

journal_title：Journal of the American College of Cardiology

authors： Lee JC,Bengtson JR,Lipscomb J,Bashore TM,Mark DB,Califf RM,Pryor DB,Hlatky MA

更新日期：1990-02-01 00:00:00

abstract：:The short-term effects of oral diltiazem on hemodynamics and distribution of cardiac output at rest and during semiupright bicycle exercise were evaluated in eight patients with stable effort angina on long-term beta 1-adrenergic blockade. Cardiac output and iliofemoral blood flow were measured using thermodilution. T...

journal_title：Journal of the American College of Cardiology

authors： Ogasawara S,Freedman SB,Ram J,Kelly DT

更新日期：1990-01-01 00:00:00

abstract：:In advanced heart failure, mitral regurgitation increases the burden of the failing ventricle and decreases effective stroke volume. Although tailored afterload reduction decreases mitral regurgitation at rest, it is not known if this benefit is maintained during upright exercise. Simultaneous radionuclide ventriculog...

journal_title：Journal of the American College of Cardiology

authors： Stevenson LW,Brunken RC,Belil D,Grover-McKay M,Schwaiger M,Schelbert HR,Tillisch JH

更新日期：1990-01-01 00:00:00

abstract：:Effects of coronary angioplasty on myocardial flow reserve have been difficult to characterize noninvasively because conventional imaging techniques cannot quantitate blood flow in absolute terms. The effects of coronary angioplasty on myocardial perfusion and perfusion reserve were delineated with positron emission t...

journal_title：Journal of the American College of Cardiology

authors： Walsh MN,Geltman EM,Steele RL,Kenzora JL,Ludbrook PA,Sobel BE,Bergmann SR

更新日期：1990-01-01 00:00:00

abstract：:The myocardial uptake of a new technetium-99m-labeled myocardial perfusion agent, methoxyisobutyl isonitrile (Tc-99m MIBI), and thallium-201 was correlated with microsphere flow in an open chest canine model of low coronary flow and postischemic dysfunction. Eighteen dogs were given an injection of thallium-201 (0.5 m...

journal_title：Journal of the American College of Cardiology

authors： Sinusas AJ,Watson DD,Cannon JM Jr,Beller GA

更新日期：1989-12-01 00:00:00

abstract：:In symptomatic severe aortic regurgitation, left ventricular diastolic pressure increases rapidly, often exceeding left atrial pressure in late diastole. This characteristic hemodynamic change should be reflected in the Doppler mitral inflow velocity, which is the direct result of the diastolic pressure difference bet...

journal_title：Journal of the American College of Cardiology

authors： Oh JK,Hatle LK,Sinak LJ,Seward JB,Tajik AJ

更新日期：1989-12-01 00:00:00

abstract：:Thrombolytic drugs given to patients with a mistaken diagnosis of acute myocardial infarction could produce adverse effects, although no such cases have been reported. Two patients treated with intravenous streptokinase for presumed but nonexistent acute myocardial infarction are described. Pericardial tamponade devel...

journal_title：Journal of the American College of Cardiology

authors： Blankenship JC,Almquist AK

更新日期：1989-11-15 00:00:00

abstract：:To evaluate the variability in the reported accuracy of the exercise electrocardiogram (ECG) for predicting severe coronary disease, meta analysis was applied to 60 consecutively published reports comparing exercise-induced ST depression with coronary angiographic findings. The 60 reports included 62 distinct study gr...

journal_title：Journal of the American College of Cardiology

authors： Detrano R,Gianrossi R,Mulvihill D,Lehmann K,Dubach P,Colombo A,Froelicher V

更新日期：1989-11-15 00:00:00

abstract：:The utility of exercise echocardiography for the diagnosis of coronary artery disease has been demonstrated in populations consisting largely of men with a high prevalence of disease. To determine the diagnostic value of exercise echocardiography in women, 57 women who presented with chest pain were studied with coron...

journal_title：Journal of the American College of Cardiology

authors： Sawada SG,Ryan T,Fineberg NS,Armstrong WF,Judson WE,McHenry PL,Feigenbaum H

更新日期：1989-11-15 00:00:00

abstract：:It has been shown that streptokinase administration at the time of acute myocardial infarction reduces mortality significantly, and that this reduction in mortality should be related to salvage of jeopardized myocardium and preservation of left ventricular function. To better define the relation between thrombolytic t...

journal_title：Journal of the American College of Cardiology

authors： Marino P,Zanolla L,Zardini P

更新日期：1989-11-01 00:00:00

abstract：:The purpose of this study was to examine whether remodeling of the aorta takes place after successful balloon angioplasty of aortic coarctation. During the 35 month period ending in December 1987, 30 children, aged 14 days to 13 years, underwent balloon angioplasty of unoperated aortic coarctation, with a resultant re...

journal_title：Journal of the American College of Cardiology

authors： Rao PS,Carey P

更新日期：1989-11-01 00:00:00

abstract：:The safety of thrombolytic therapy of acute myocardial infarction could be improved if a method were developed to dissolve fresh occlusive coronary thrombus without simultaneously dissolving hemostatic thrombi outside the coronary arteries. This study is based on the assumption that, in a patient with evolving acute m...

journal_title：Journal of the American College of Cardiology

authors： Kanamasa K,Watanabe I,Cercek B,Yano J,Fishbein MC,Ganz W

更新日期：1989-11-01 00:00:00

abstract：:Nicardipine, a new dihydropyridine calcium channel blocker, has been investigated for the treatment of coronary artery disease and heart failure. To assess the inotropic effect of nicardipine in humans independent of its vasodilator effect, equihypotensive doses of intravenous nitroprusside (mean infusion rate 65 +/- ...

journal_title：Journal of the American College of Cardiology

authors： Aroney CN,Semigran MJ,Dec GW,Boucher CA,Fifer MA

更新日期：1989-11-01 00:00:00

abstract：:The purposes of this study were 1) to determine the prognosis of silent ischemia in an unselected group of patients referred for exercise testing, and 2) to assess whether age or the presence of myocardial infarction or diabetes mellitus influences the prevalence of silent myocardial ischemia during exercise testing. ...

journal_title：Journal of the American College of Cardiology

authors： Callaham PR,Froelicher VF,Klein J,Risch M,Dubach P,Friis R

更新日期：1989-11-01 00:00:00

abstract：:To determine the reproducibility of two-dimensional exercise echocardiography, duplicate studies were performed on the same patients a median of 14 days apart. Because measurements are operator-dependent, interobserver variability was calculated for two experienced readers who interpreted the findings independently in...

journal_title：Journal of the American College of Cardiology

authors： Oberman A,Fan PH,Nanda NC,Lee JY,Huster WJ,Sulentic JA,Storey OF

更新日期：1989-10-01 00:00:00

abstract：:Decision analysis, an analytic approach to making decisions when uncertainty is present, has its foundation in probability and utility theory. It provides insights into the trade-offs that are involved when a selection must be made among patient management strategies. In general, several broad steps are involved. The ...

journal_title：Journal of the American College of Cardiology

authors： Moskowitz AJ,Pauker SG

更新日期：1989-09-01 00:00:00

abstract：:Data are required for a meaningful approach to quality and cost-conscious cardiovascular care. How to identify the types of data available and their sources, advantages and limitations to their use, issues involved in combining data from different sources for decision modeling and some possible solutions are discussed...

journal_title：Journal of the American College of Cardiology

authors： Muhlbaier LH,Pryor DB

更新日期：1989-09-01 00:00:00

abstract：:Seventeen patients (16 men and 1 woman) were challenged with isoproterenol after their initially inducible sustained ventricular tachyarrhythmia (monomorphic tachycardia in 14 patients and fibrillation in 3) was completely suppressed by class I antiarrhythmic drugs. Coronary artery disease was documented in 11 patient...

journal_title：Journal of the American College of Cardiology

authors： Jazayeri MR,Van Wyhe G,Avitall B,McKinnie J,Tchou P,Akhtar M

更新日期：1989-09-01 00:00:00

abstract：:To investigate the relation between basal coronary artery diameter and development of coronary artery spasm, the diameters of the proximal, middle and distal segments of the three major coronary artery branches, together with that of the left main trunk, were measured on a control angiogram and after ergonovine and ni...

journal_title：Journal of the American College of Cardiology

authors： Hoshio A,Kotake H,Mashiba H

更新日期：1989-09-01 00:00:00

abstract：:Quality care reemerges as an issue amid the primary concern for cost. Primary problems revolve around whether treatments are efficacious and appropriate for the individual patient and whether the practice of medicine is being performed competently. A model is suggested for how these questions might be addressed. ...

journal_title：Journal of the American College of Cardiology

authors： Neuhauser D,Napier K

更新日期：1989-09-01 00:00:00

abstract：:The effects of combined intravenous and intracoronary streptokinase without (Group I, n = 103) or with (Group II, n = 103) immediate coronary angioplasty were evaluated during a long-term (3 year) follow-up of 206 patients with acute transmural myocardial infarction. There were no baseline differences between the grou...

journal_title：Journal of the American College of Cardiology

authors： Erbel R,Pop T,Diefenbach C,Meyer J

更新日期：1989-08-01 00:00:00

abstract：:To clarify the role of serotonin in eliciting myocardial ischemia, the effects of serotonin on coronary vasculature and cardiac performance were examined in anesthetized open chest dogs. Without coronary stenosis, intracoronary infusion of serotonin (0.001 to 1.0 micrograms/kg per min) for 40 s caused dose-dependent i...

journal_title：Journal of the American College of Cardiology

authors： Ichikawa Y,Yokoyama M,Akita H,Fukuzaki H

更新日期：1989-08-01 00:00:00

abstract：:The failure of exercise-induced ST segment depression to consistently predict prognosis in patients after myocardial infarction could be a result of population differences and the rest electrocardiogram (ECG). These hypotheses were tested by studying 198 veterans who survived a myocardial infarction, underwent a subma...

journal_title：Journal of the American College of Cardiology

authors： Klein J,Froelicher VF,Detrano R,Dubach P,Yen R

更新日期：1989-08-01 00:00:00

abstract：:Forty patients with coronary artery disease and nonsustained ventricular tachycardia on ambulatory electrocardiographic monitoring underwent programmed electrical stimulation. In 22 patients, monomorphic ventricular tachycardia was induced at baseline drug-free electrophysiologic testing; 9 of these patients subsequen...

journal_title：Journal of the American College of Cardiology

authors： Klein RC,Machell C

更新日期：1989-07-01 00:00:00

abstract：:Patients with diabetes mellitus experience a more adverse outcome after acute myocardial infarction compared with nondiabetic patients, although the mechanisms responsible for these findings are not clear. From the Multicenter Investigation of the Limitation of Infarct Size (MILIS) study, the course of acute infarctio...

journal_title：Journal of the American College of Cardiology

authors： Stone PH,Muller JE,Hartwell T,York BJ,Rutherford JD,Parker CB,Turi ZG,Strauss HW,Willerson JT,Robertson T

更新日期：1989-07-01 00:00:00

abstract：:Drug efficacy and pharmacokinetics were assessed in 63 patients, aged 5 days to 30 years (mean 8 years), who received flecainide acetate for control of resistant arrhythmias. Doses of flecainide ranged from 59 to 225 mg/m2 body surface area per day (mean 141) in divided doses every 8 to 12 h and serum trough levels ra...

journal_title：Journal of the American College of Cardiology

authors： Perry JC,McQuinn RL,Smith RT Jr,Gothing C,Fredell P,Garson A Jr

更新日期：1989-07-01 00:00:00